Toxoplasma gondii (TG), Rubella virus (RV), cytomegalovirus (CMV), and herpes simplex virus types 1 and 2 (HSV 1 and 2) are generally mild in immunocompetent adults, but can lead to serious complications for the fetus and newborn when they occur during pregnancy. This study aims to determine the seroprevalence of these infections in pregnant women, commonly referred to by the acronym TORCH, by analyzing their serological profile in IgM and IgG. To achieve this, 83 samples were obtained from two collection sites in Yaoundé from the serological bank of the Microbiology Laboratory of the University of Yaoundé 1 and analyzed. The One Step Rapid Test Kit from EVANCARE was used. The survey sheets accompanying the plasma samples were used to associate the risk factors in this population. The results obtained regarding the IgG seroprevalence of TORCH infections in our samples were as follows: Toxoplasmosis IgG 34.9%, Rubella IgG 28.9%, Cytomegalovirus IgG 28.9% and HSV1 IgG 30.1%. Only HSV1 showed an IgM seropositivity (1.2%). These results were totally negative for both HSV2 IgM and HSV2 IgG testing. Factors associated with the acquisition of these pathogens and the production of IgG antibodies were: urban area of residence, contact with soil, consumption of raw or undercooked meat, contact with domestic animals, the last two trimesters of pregnancy, and blood transfusion. This study contributed to a better understanding of the prevalence and risk factors of TORCH infections in pregnant women in Yaoundé.