One important component in the pathophysiology of diseases affecting the mucosa of the stomach is oxidative damage. oxygen species that react (ROS) are produced as metabolic byproducts of regular cellular activity. Catalase, glutathione peroxidase, and superoxide dismutase are the enzymes that help shield cells from the harmful effects of ROS. In response to UV light, `tobacco smoke, alcohol, NSAIDs medications, IR injury, persistent infections, and inflammatory diseases, ROS are generated. Redox signalling's disruption of normal cellular equilibrium can lead to cancer, neurological illnesses, and heart problems. Although the gastrointestinal (GI) tract produces ROS, little is known about how these molecules function in pathophysiology and the genesis of disease. We have covered certain medicinal plants in this review article that have been shown to have antiulcer action due to their antioxidant properties, as well as the function that free radicals play in ulcers that are scavenged by antioxidants found in the herbs. Antioxidants and oxidative stress play a complicated and multidimensional role in ulcers. Antioxidants are important preventive factors against ulcer development, however oxidative stress also plays a major role. To precisely understand the processes causing oxidative damage in ulcers and to create customised antioxidant-based treatments for ulcer management and prevention, more study is required.