Objectives: The aim of this study was to assess and compare scientific output of research on infertility with modern day works as against a project work done by (Yamoah 1989) (not yet published) on infertility using a case study from two health centers using herbal and orthodox medicines in the treatment of infertility in Kumasi, Ashanti region of Ghana in the year 1989. Method: Research publications on infertility from 2011 to 2024 were retrieved from the Web of Science Core Collection (WoSCC). Pub med, Google scholar. In all about 120 articles, books and conference materials on modern day infertility diagnosis, treatment and recommendations were used. Results: Out of the total of 120 articles related to the study of infertility, the researchers saw a sharp rise in the number of publications on the subject matter from 2013 to 2023 with a stable trend. The study conducted by Yamoah J in 1989 (not yet published) revealed no significant variation in the incidence of infertility among the months of any particular year. Conclusion: The researchers agree with the modern day clinical work on infertility as done by (Walker and Tobler, 2022), (Boivin et al., 2020), (Yuan et al., 2016), (Eiser et al., 2011), (Van den Broeck et al., 2010). The researchers admit the fact as shown in epigenetics that the environment is a predictor to either infertility or fertility and with life style changes, especially avoidance of sedentary life style becomes a major intervention to break the barriers of infertility in both male and females.