This study synthesizes interdisciplinary evidence on game-based interventions for military veterans, mapping neurological mechanisms to clinically relevant outcomes while outlining design principles for community programs that leverage interactive media. The review characterizes how structured gameplay supports emotional regulation through attentional control, predictable feedback schedules, and reward-mediated learning that elevates motivation and mood; links to dopaminergic signaling and reduced rumination suggest plausible pathways for affective stabilization. Executive functions receive targeted engagement via strategy, puzzle, and action mechanics that demand working memory, cognitive flexibility, inhibition, and rapid decision-making, providing ecologically valid practice with measurable transfer to daily functioning. Social architectures in multiplayer platforms and veteran-centered guilds reconstruct mission-oriented cohesion, improve perceived belonging, and decrease isolation, especially when paired with moderated peer support. Adaptive accessibility—exemplified by modular controllers, alternative input devices, and custom mappings—enables participation for veterans with mobility or sensory limitations and doubles as engaging adjunctive therapy for motor relearning and coordination. Virtual reality exposure systems operationalize graded, therapist-controlled re-engagement with trauma cues, combining presence, controllability, and biofeedback to enhance adherence and symptom reduction. Risk management addresses overuse, sleep disruption, and avoidance by embedding gaming within accountable routines, transparent goal-setting, and clinician or peer oversight. The article culminates in a translational framework—Veterans Play & Heal—that integrates creative game design workshops, therapeutic play sessions, adaptive equipment libraries, and museum or arts partnerships to align entertainment technology with rehabilitation, resilience, and identity reconstruction.