Hypertension is one of the non-communicable diseases that is the leading cause of death globally. This study aims to determine the effect of giving vegetable juice and probiotic red dragon fruit juice on blood pressure in prehypertensive patients. The design of this research subject group is prehypertension patients with Systolic blood pressure >120mmHg and Diastolic >80mmHg which is divided into 4 treatment groups namely PO, P1, P2, P3 groups. The doses given were PO leaflet education, P1 200ml vegetable juice and leaflet education, P2 200ml probiotic red dragon fruit juice and leaflet education, P3 200ml vegetable juice and probiotic red dragon fruit juice and leaflet education. The intervention was conducted for 7 days. Blood pressure measurements using a Sphygmomanometer, checking blood pressure before and after the intervention. Normality test was performed using Shapiro-Wilk. Statistical analysis using ANOVA test and followed by Duncan test. The results showed the average before the intervention P0 137/87mmHg, P1 137/83mmHg, P2 137/87mmHg, P3 137/85mmHg. Average Systolic and Diastolic blood pressure in the prehypertension group after the intervention P0 132/85mmHg, P1 126/82mmHg, P2 127/84, P3 121/79 mmHg with Systolic blood pressure P-value = 0.002 and Diastolic blood pressure P-value = 0.010. Of the 4 treatments, the best treatment was the P3 treatment. It can be concluded that there is an effect of giving vegetable juice and probiotic red dragon fruit juice on blood pressure in prehypertensive patients in the work area of the Telaga Dewa Health Center, Bengkulu City.